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It is estimated that 3,000,000 people use anabolic steroids in America each year, but only approximately 100 cases of anabolic Steroid Related Disease are ever reported as a result. "Anabolic steroid use can have serious side effects," stated Dr. Thomas H. Kroll, the founder and medical director of the Sports Medicine Program at Columbia University Medical Center in New York City and a world class expert in the study of drug related Diseases in Sports. "These side effects include the following: liver damage, kidney damage, adrenal problems, cardiovascular problems, bone marrow damage, muscle weakness and atrophy, mental and physical retardation… In addition, many of these side effects can have serious long term consequences. The use of anabolic steroids can cause these problems to occur during adolescence. These negative effects of anabolic steroids also have been observed in men and women of advanced reproductive age in Europe and Japan. Many studies have found that older people who smoke are more prone to developing severe anabolic steroid related diseases as compared to younger people." The U.S. population is aging, and it appears that steroids will continue to be one of the factors that contributes to an increase in anabolic steroid related diseases. The majority of the health consequences associated with prolonged or excessive use of anabolic steroids are due to the drug interactions with other drugs and body systems involved in hormone signaling, including but not limited to liver, heart, adrenal, kidney, thyroid, and muscle tissue. Anabolic steroid use has been associated with numerous health issues including increased cardiovascular risk, liver damage, kidney damage, adrenal damage, increased blood pressure, increased weight gain, and increased incidence of diabetes and cardiovascular disease. For information on the effects of anabolic steroid use on the heart, see the section below titled "Heart Concerns" Anabolic steroids play a significant role in the development of the pituitary gland and the adrenal glands in humans by modifying the hormone levels in the adrenal steroids that are responsible for the production of corticotropin-releasing hormone (CRH), glucocorticoid hormones and other hormones. When this change occurs, corticotropic-induced activity in the adrenal glands is inhibited causing adrenal insufficiency (low androgen responsiveness). This process, in turn, is associated with increased stress hormones and a greater chance of developing adrenal insufficiency (low androgen responsiveness), a condition that is the leading cause of death in males as well as a leading cause of death in females. Steroid use has been shown to produce an inflammatory response that wors Related Article: